Chris Matranga – Sabeti Lab

CHRIS MATRANGA, Ph.D.

Chris.Matranga

Chris Matranga is a research scientist in the Sabeti Lab and the viral genomics group at the Broad Institute. He received his Ph.D. from UMass Medical School and was awarded an NRSA NIH fellowship for his postdoctoral research at Yale University. Chris has developed methods currently used to sequence Lassa and Ebola clinical samples.
When away from the bench, Chris enjoys spending time with his family and playing ice hockey.

SELECTED PUBLICATIONS

Double-stranded RNA-dependent ATPase DRH-3: insight into its role in RNAsilencing in Caenorhabditis elegans.

J Biol Chem. 2010.
Matranga C, Pyle AM.

Small silencing RNAs.

Curr Biol. 2007.
Matranga C, Zamore PD.

The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC.

Curr Biol. 2007.
Horwich MD, Li C, Matranga C*, Vagin V, Farley G, Wang P, Zamore PD.

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes.

Cell. 2005.
Matranga C, Tomari Y, Shin C, Bartel DP, Zamore PD.

A protein sensor for siRNA asymmetry

Science. 2004.
Tomari Y, Matranga C, Haley B, Martinez N, Zamore PD.

Plant RNA interference in vitro.

Cold Spring Harb Symp Quant Biol. 2004.
Matranga C, Zamore PD.

Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity.

Cancer Res. 2003.
Jiang J, Matranga CB, Cai D, Latham VM Jr, Zhang X, Lowell AM, Martelli F, Shapiro GI.

Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase.

Cancer Res. 2002
Matranga CB, Shapiro GI.

Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines.

Clin Cancer Res. 1999
Shapiro GI, Koestner DA, Matranga CB, Rollins BJ.
*Equal contribution

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