Ryan Tewhey is a postdoctoral fellow in the Sabeti lab who works on the discovery and functional characterization of genetic variation in host and pathogens. His primary focus is on the development of large scale functional screening systems of non-coding variation. His time is evenly divided between wet and dry lab approaches.
Ryan completed a dual major in Cellular Biology and Biochemistry at the University of Maine, Orono and then worked for two years at the Broad Institute assisting with the first genome wide association studies for type II diabetes. He received his PhD from the Division of Biological Science at University of California, San Diego in 2012 while carrying out work at the Scripps Translational Science Institute at the Scripps Research Institute. Here he developed technologies for high-throughput sequencing studies, using the technology to study human complex diseases as well as microbial pathogenesis and resistance. He was named to Forbes Magazine’s 30 under 30 rising stars in science in 2011 and has conducted research at the Genome Institute of Singapore as a recipient of a NSF/A-STAR EAPSI fellowship.
Bright AT, Tewhey R, Abeles S, Chuquiyauri R, Llanos-Cuentas A, Ferreira MU, Schork NJ, Vinetz JM, Winzeler EA.
Whole genome sequencing analysis of Plasmodium vivax using whole genome capture.
BMC Genomics. 2012 Jun 21;13:262.
Bansal V, Tewhey R, Leproust EM, Schork NJ.
Efficient and cost effective population resequencing by pooling and in-solution hybridization.
PLoS One. 2011 Mar 30;6(3):e18353.
Tewhey R, Bansal V, Torkamani A, Topol EJ, Schork NJ.
The importance of phase information for human genomics.
Nat Rev Genet. 2011 Mar;12(3):215-23.
Sim BM, Chantratita N, Ooi WF, Nandi T, Tewhey R, Wuthiekanun V, Thaipadungpanit J, Tumapa S, Ariyaratne P, Sung WK, Sem XH, Chua HH, Ramnarayanan K, Lin CH, Liu Y, Feil EJ, Glass MB, Tan G, Peacock SJ, Tan P.
Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates.
Genome Biol. 2010;11(8):R89.
Tewhey R, Warner JB, Nakano M, Libby B, Medkova M, David PH, Kotsopoulos SK, Samuels ML, Hutchison JB, Larson JW, Topol EJ, Weiner MP, Harismendy O, Olson J, Link DR, Frazer KA.
Microdroplet-based PCR enrichment for large-scale targeted sequencing.
Nat Biotechnol. 2009 Nov;27(11):1025-31. Epub 2009 Nov 1. Erratum in: Nat Biotechnol. 2010 Feb;28(2):178.
Tewhey R, Nakano M, Wang X, Pabón-Peña C, Novak B, Giuffre A, Lin E, Happe S, Roberts DN, LeProust EM, Topol EJ, Harismendy O, Frazer KA.
Enrichment of sequencing targets from the human genome by solution hybridization.
Genome Biol. 2009;10(10):R116.