Ryan Tewhey is a postdoctoral fellow in the Sabeti lab who works on the discovery and functional characterization of genetic variation in host and pathogens. His primary focus is on the development of large scale functional screening systems for non-coding variation. His time is evenly divided between wet and dry lab approaches.
Ryan completed a dual major in Cellular Biology and Biochemistry at the University of Maine, Orono and then worked for two years at the Broad Institute assisting with the first genome wide association studies for type II diabetes. He received his PhD from the Division of Biological Science at University of California, San Diego in 2012 while carrying out work at the Scripps Translational Science Institute at the Scripps Research Institute. Here he developed technologies for high-throughput sequencing studies and using the technologies to study human complex diseases as well as microbial pathogenesis. He was named to Forbes Magazine's 30 under 30 rising stars in science in 2011 and has conducted research at the Genome Institute of Singapore as a recipient of a NSF/A-STAR EAPSI fellowship.
De novo finished 2.8 Mbp Staphylococcus aureus genome assembly from 100 bp short and long range paired-end reads.
Bioinformatics. 2013 Oct 15.
Hernandez D, Tewhey R, Veyrieras JB, Farinelli L, Osterås M, François P,
Evidence for the role of EPHX2 gene variants in anorexia nervosa.
Mol Psychiatry. 2013.
Scott-Van Zeeland AA, Bloss CS, Tewhey R, Bansal V, Torkamani A, Libiger O, Duvvuri V, Wineinger N, Galvez L, Darst BF, Smith EN, Carson A, Pham P, Phillips T, Villarasa N, Tisch R, Zhang G, Levy S, Murray S, Chen W, Srinivasan S, Berenson G, Brandt H, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB, Bulik CM, Keel P, Klump KL, Lilenfeld L, Plotnicov K, Topol EJ, Shih PB, Magistretti P, Bergen AW, Berrettini W, Kaye W, Schork NJ.
Evolution of high-level daptomycin resistance in Enterococcus faecium during daptomycin therapy is associated with limited mutations in the bacterial genome.
J Antimicrob Chemother. 2013
Kelesidis T, Tewhey R, Humphries RM.
Alternative mutational pathways to intermediate resistance to vancomycin in methicillin-resistant Staphylococcus aureus. J Infect Dis. 2013.
Vidaillac C, Gardete S, Tewhey R, Sakoulas G, Kaatz GW, Rose WE, Tomasz A,
Clinical implications of human population differences in genome-wide rates of functional genotypes. Front Genet. 2012.
Torkamani A, Pham P, Libiger O, Bansal V, Zhang G, Scott-Van Zeeland AA,
Tewhey R, Topol EJ, Schork NJ.
Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300. BMC Genomics. 2012.
Tewhey R, Cannavino CR, Leake JA, Bansal V, Topol EJ, Torkamani A, Bradley JS, Schork NJ.
Whole genome sequencing analysis of Plasmodium vivax using whole genome capture. BMC Genomics. 2012.
Bright AT, Tewhey R, Abeles S, Chuquiyauri R, Llanos-Cuentas A, Ferreira MU, Schork NJ, Vinetz JM, Winzeler EA.
Efficient and cost effective population resequencing by pooling and in-solution hybridization. PLoS One. 2011.
Bansal V, Tewhey R, Leproust EM, Schork NJ.
The importance of phase information for human genomics. Nat Rev Genet. 2011.
Tewhey R, Bansal V, Torkamani A, Topol EJ, Schork NJ.
Microdroplet-based PCR enrichment for large-scale targeted sequencing. Nat Biotechnol. 2009.
Tewhey R, Warner JB, Nakano M, Libby B, Medkova M, David PH, Kotsopoulos SK, Samuels ML, Hutchison JB, Larson JW, Topol EJ, Weiner MP, Harismendy O, Olson J, Link DR, Frazer KA.
Enrichment of sequencing targets from the human genome by solution hybridization. Genome Biol. 2009.
Tewhey R, Nakano M, Wang X, Pabón-Peña C, Novak B, Giuffre A, Lin E, Happe S, Roberts DN, LeProust EM, Topol EJ, Harismendy O, Frazer KA.