Kristian Andersen

Kristian G. Andersen is a postdoctoral researcher at FAS Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard University and the Broad Institute. Originally from Denmark, he received his PhD from the University of Cambridge and MRC Laboratory of Molecular Biology in 2009. Here, he worked on mechanisms of immunological tolerance and the evolution of the adaptive immune system.

Since moving to Harvard he has been investigating the complex relationship between host and pathogen. Using a combination of experimental and computational techniques he is investigating how the human immune system impacts the evolution of viral pathogens such as Lassa and Ebola. Given the strong selection pressures caused by these microorganisms, he is also investigating signals of natural selection in the human genome in response to infectious agents.

He was awarded the Carlsberg Foundation Scholarship from 2005-2008 and Postdoctoral Fellowship from 2009-2011. In 2008 he received the Max Perutz Prize for Outstanding Graduate Research.

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science. 2014.
Gire SK, Goba A, Andersen KG, Sealfon RS, Park DJ, Kanneh L, Jalloh S, Momoh M, Fullah M, Dudas G, Wohl S, Moses LM, Yozwiak NL, Winnicki S, Matranga CB, Malboeuf CM, Qu J, Gladden AD, Schaffner SF, Yang X, Jiang PP, Nekoui M, Colubri A, Coomber MR, Fonnie M, Moigboi A, Gbakie M, Kamara FK, Tucker V, Konuwa E, Saffa S, Sellu J, Jalloh AA, Kovoma A, Koninga J, Mustapha I, Kargbo K, Foday M, Yillah M, Kanneh F, Robert W, Massally JL, Chapman SB, Bochicchio J, Murphy C, Nusbaum C, Young S, Birren BW, Grant DS, Scheiffelin JS, Lander ES, Happi C, Gevao SM, Gnirke A, Rambaut A, Garry RF, Khan SH, Sabeti PC.

Identifying recent adaptations in large-scale genomic data. Cell 2013.
Grossman SR*, Andersen KG*, Shlyakhter I*, Tabrizi S*, Winnicki S, Yen A, Park DJ, Griesemer D, Karlsson EK, Wong SH, Cabili M, Adegbola RA, Bamezai RNK, Hill AVS, Vannberg FO, Rinn JL, 1000 Genomes Project, Lander ES, Schaffner SF, Sabeti PC. (*equal contribution).

Epidemiology. Emerging disease or diagnosis? Science 2012.
Gire SK, Stremlau M, Andersen KG, Schaffner SF, Bjornson Z, Rubins K, Hensley L, McCormick JB, Lander ES, Garry RF, Happi C, Sabeti PC.

Foxp3 expression is required for the induction of therapeutic tissue tolerance.
J Immunol 2012.
Regateiro FS, Ye Chen Y, Kendal AR, Hilbrands R, Adams E, Cobbold SP, Ma J, Andersen KG, Betz AG, Zhang M, Madhiwalla S, Roberts B, Waldmann H, Nolan KF, Howie D.

Activation rather than Foxp3 expression determines that TGF-β-induced regulatory T cells out-compete naïve T cells in dendritic cell clustering. Eur J Immunol 2012.
Chen Y, Adams E, Regateiro FS, Vaux DJ, Betz AG, Andersen KG, Waldmann H, Howie D.

Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever. Philos Trans R Soc Lond B Biol Sci. 2012.
Andersen KG, Shylakhter I, Tabrizi S, Grossman SR, Happi CT, Sabeti PC

Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation. PLoS Negl Trop Dis. 2012.
Asogun DA, Adomeh DI, Ehimuan J, Odia I, Hass M, Gabriel M, Olschläger S, Becker-Ziaja B, Folarin O, Phelan E, Ehiane PE, Ifeh VE, Uyigue EA, Oladapo YT, Muoebonam EB, Osunde O, Dongo A, Okokhere PO, Okogbenin SA, Momoh M, Alikah SO, Akhuemokhan OC, Imomeh P, Odike MA, Gire S, Andersen K, Sabeti PC, Happi CT, Akpede GO, Günther S

Lassa hemorrhagic fever in a late term pregnancy from northern Sierra Leone with a positive maternal outcome: case report. Virol J. 2011.
Branco LM, Boisen ML, Andersen KG, Grove JN, Moses LM, Muncy IJ, Henderson LA, Schieffellin JS, Robinson JE, Bangura JJ, Grant DS, Raabe VN, Fonnie M, Sabeti PC, Garry RF

Foxp3 interacts with c-Rel to mediate NF-κB repression. PLoS One. 2011.
Loizou L*, Andersen KG*, Betz AG (*equal contribution).

Methods Of Switching The Phenotype Of T Cells By Transgenic Lineage Factor Foxp3
Patent application #20100203068.
Betz AG, Andersen KG

LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. J Biol Chem. 2008.
Hebenstreit D, Giaisi M, Treiber MK, Zhang XB, Mi HF, Horejs-Hoeck J, Andersen KG, Duschl A, Li-Weber M

Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus. Proc Natl Acad Sci U S A. 2007.
Kallikourdis M, Andersen KG, Welch KA, Betz AG