Kristian G. Andersen is a postdoctoral researcher at FAS Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard University and the Broad Institute. Originally from Denmark, he received his PhD from the University of Cambridge and MRC Laboratory of Molecular Biology in 2009. Here, he worked on mechanisms of immunological tolerance and the evolution of the adaptive immune system.
Since moving to Harvard he has been investigating the complex relationship between host and pathogen. Using a combination of experimental and computational techniques he is investigating how the human immune system impacts the evolution of viral pathogens such as Lassa and Ebola. Given the strong selection pressures caused by these microorganisms, he is also investigating signals of natural selection in the human genome in response to infectious agents.
He was awarded the Carlsberg Foundation Scholarship from 2005-2008 and Postdoctoral Fellowship from 2009-2010. In 2008 he received the Max Perutz Prize for Outstanding Graduate Research.
Foxp3 expression is required for the induction of therapeutic tissue tolerance.
Regateiro FS, Ye Chen Y, Kendal AR, Hilbrands R, Adams E, Cobbold SP, Ma J, Andersen KG, Betz AG, Zhang M, Madhiwalla S, Roberts B, Waldmann H, Nolan KF, Howie D
J. Immunol. (in press)
Activation rather than Foxp3 expression determines that TGF-β-induced regulatory T cells out-compete naïve T cells in dendritic cell clustering.
Chen Y, Adams E, Regateiro FS, Vaux DJ, Betz AG, Andersen KG, Waldmann H, Howie D (2012)
Eur J Immunol. 42:1436-48.
Comparative genomics reveals key gain-of-function events in Foxp3 during regulatory T cell evolution.
Andersen KG, Nissen JK, Betz AG (2012)
Front. Immun. 3:113.
Genome-wide scans provide evidence ￼￼￼￼￼￼￼￼￼￼￼￼￼￼￼for positive selection of genes implicated in Lassa fever.
Andersen KG, Shylakhter I, Tabrizi S, Grossman SR, Happi CT, Sabeti PC
Phil. Trans. R. Soc. B (2011)
Lassa hemorrhagic fever in a late term pregnancy from northern Sierra Leone with a positive maternal outcome: case report.
Branco LM, Boisen ML, Andersen KG, Grove JN, Moses LM, Muncy IJ, Henderson LA, Schieffellin JS, Robinson JE, Bangura JJ, Grant DS, Raabe VN, Fonnie M, Zaitsev EM, Sabeti PC, Garry RF.
Virol J. 2011 Aug 15;8:404.
Foxp3 interacts with c-Rel to mediate NF-κB repression.
Loizou L, Andersen KG, Betz AG.
PLoS One. 2011 Apr 7;6(4):e18670.
Specific immunosuppression with inducible Foxp3-transduced polyclonal T cells.
Andersen KG, Butcher T, Betz AG.
PLoS Biol. 2008 Nov 11;6(11):e276.
LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element.
Hebenstreit D, Giaisi M, Treiber MK, Zhang XB, Mi HF, Horejs-Hoeck J, Andersen KG, Krammer PH, Duschl A, Li-Weber M.
J Biol Chem. 2008 Aug 15;283(33):22490-7.
Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition.
Sarris M, Andersen KG, Randow F, Mayr L, Betz AG.
Immunity. 2008 Mar;28(3):402-13.
Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus.
Kallikourdis M, Andersen KG, Welch KA, Betz AG.
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):594-9.