Chris Matranga

Chris Matranga is a research scientist collaborating closely with the Sabeti Group. Chris is interested in all things RNA, and its potential as a therapeutic tool and as a molecular target for the prevention and treatment of viral disease. A trained biochemist and molecular biologist, Chris received his PhD from UMass Medical School and was awarded an NRSA NIH fellowship for his postdoctoral studies at Yale University. He is currently working with the Molecular Biology R&D group in the Broad Technology Labs. Chris is developing methods that will support viral genomic projects in the Sabeti Lab.

When away from the bench, Chris enjoys spending time with his young family and playing ice hockey year round.


Small silencing RNAs. Curr Biol. 2007.
Matranga C, Zamore PD.

The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Curr Biol. 2007.
Horwich MD*, Li C*, Matranga C*, Vagin V, Farley G, Wang P, Zamore PD.

A protein sensor for siRNA asymmetry. Science. 2004.
Tomari Y, Matranga C, Haley B, Martinez N, Zamore PD.

Plant RNA interference in vitro. Cold Spring Harb Symp Quant Biol. 2004.
Matranga C, Zamore PD.

Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity. Cancer Res. 2003.
Jiang J*, Matranga CB*, Cai D, Latham VM Jr, Zhang X, Lowell AM, Martelli F, Shapiro GI.

Flavopiridol induces cell cycle arrest and p53-independent apoptosis in non-small cell lung cancer cell lines. Clin Cancer Res. 1999
Shapiro GI, Koestner DA, Matranga CB, Rollins BJ.

*Equal contribution