Danny Park studies the evolution of infectious diseases that cause a significant human burden. Most of his years with the Sabeti Lab have focused on the emergence of drug resistance in the P. falciparum malaria parasite. He has used and developed computational genomic tools to identify the adaptations used by the parasite to evade modern drugs and global eradication efforts. Recently, he has become more involved in studies of viral evolution, such as our analysis of Ebola virus in West Africa.
Danny originally worked with the Sabeti Lab as a software engineer at the Broad, then as a Harvard graduate student, and finally, as a computational biologist at the Broad. Prior to the Broad, he spent four years at a microarray core facility at MGH, working as a bioinformatic consultant on the design and analysis of expression experiments. His bachelor's and master's degrees are in computer science from MIT, where he developed software tools for in silico protein design in the Keating Lab.
He lives in Cambridge with his wife and son and chairs the board of his church in Arlington.
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science. 2014.
Gire SK, Goba A, Andersen KG, Sealfon RS, Park DJ, Kanneh L, Jalloh S, Momoh M, Fullah M, Dudas G, Wohl S, Moses LM, Yozwiak NL, Winnicki S, Matranga CB, Malboeuf CM, Qu J, Gladden AD, Schaffner SF, Yang X, Jiang PP, Nekoui M, Colubri A, Coomber MR, Fonnie M, Moigboi A, Gbakie M, Kamara FK, Tucker V, Konuwa E, Saffa S, Sellu J, Jalloh AA, Kovoma A, Koninga J, Mustapha I, Kargbo K, Foday M, Yillah M, Kanneh F, Robert W, Massally JL, Chapman SB, Bochicchio J, Murphy C, Nusbaum C, Young S, Birren BW, Grant DS, Scheiffelin JS, Lander ES, Happi C, Gevao SM, Gnirke A, Rambaut A, Garry RF, Khan SH, Sabeti PC.
Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci U S A. 2012.
Park DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C, Ribacke U, Van Tyne D, Galinsky K, Galligan M, Becker JS, Ndiaye D, Mboup S, Wiegand RC, Hartl DL, Sabeti PC, Wirth DF, Volkman SK.
Harnessing genomics and genome biology to understand malaria biology. Nat Rev Genet. 2012.
Volkman SK1, Neafsey DE, Schaffner SF, Park DJ, Wirth DF.
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet. 2011.
Van Tyne D1, Park DJ, Schaffner SF, Neafsey DE, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA Jr, Johnson CA, Shlyakhter I, Grossman SR, Becker JS, Yamins D, Karlsson EK, Ndiaye D, Sarr O, Mboup S, Happi C, Furlotte NA, Eskin E, Kang HM, Hartl DL, Birren BW, Wiegand RC, Lander ES, Wirth DF, Volkman SK, Sabeti PC.