The Sabeti Lab, headed by Pardis Sabeti, is part of the FAS Center for Systems Biology at Harvard University, and maintains close ties to the Eli and Edyth Broad Institute of Harvard and MIT. Founded in early 2008, the lab is the newest addition to the Center for Systems Biology, which is located in Cambridge, MA at Harvard's state-of-the-art science facility, the Northwest Building, which was completed in the summer of 2008.
The goals of The Sabeti Lab are to use computational methods and genomics to understand mechanisms of evolutionary adaptation in humans and pathogens. We are pursuing these goals through 3 research foci:
- Developing analytical and experimental methods to detect and investigate natural selection in the genome of humans and other species.
- Examining host and viral genetic factors driving resistance to Lassa Fever in West Africa.
- Examining signals of natural selection in pathogens, including Lassa virus, Ebola virus, and Plasmodium falciparum malaria to understand how they rapidly evolve, and studying their genetic diversity to guide long term intervention strategies.